1tba

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[[Image:1tba.jpg|left|200px]]
[[Image:1tba.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tba OCA], [http://www.ebi.ac.uk/pdbsum/1tba PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tba RCSB]</span>
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'''SOLUTION STRUCTURE OF A TBP-TAFII230 COMPLEX: PROTEIN MIMICRY OF THE MINOR GROOVE SURFACE OF THE TATA BOX UNWOUND BY TBP, NMR, 25 STRUCTURES'''
'''SOLUTION STRUCTURE OF A TBP-TAFII230 COMPLEX: PROTEIN MIMICRY OF THE MINOR GROOVE SURFACE OF THE TATA BOX UNWOUND BY TBP, NMR, 25 STRUCTURES'''
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[[Category: Nakatani, Y.]]
[[Category: Nakatani, Y.]]
[[Category: Tong, K I.]]
[[Category: Tong, K I.]]
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[[Category: complex (transcription factors)]]
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[[Category: Nmr]]
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[[Category: nmr]]
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[[Category: Solution structure]]
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[[Category: solution structure]]
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[[Category: Taf]]
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[[Category: taf]]
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[[Category: Tafii230]]
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[[Category: tafii230]]
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[[Category: Tbp]]
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[[Category: tbp]]
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[[Category: Tfiid]]
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[[Category: tfiid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:45:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:53:51 2008''
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Revision as of 06:45, 3 May 2008

Image:1tba.jpg

Template:STRUCTURE 1tba

SOLUTION STRUCTURE OF A TBP-TAFII230 COMPLEX: PROTEIN MIMICRY OF THE MINOR GROOVE SURFACE OF THE TATA BOX UNWOUND BY TBP, NMR, 25 STRUCTURES


Overview

General transcription factor TFIID consists of TATA box-binding protein (TBP) and TBP-associated factors (TAF(II)s), which together play a central role in both positive and negative regulation of transcription. The N-terminal region of the 230 kDa Drosophila TAF(II) (dTAF(II)230) binds directly to TBP and inhibits TBP binding to the TATA box. We report here the solution structure of the complex formed by dTAF(II)230 N-terminal region (residues 11-77) and TBP. dTAF(II)230(11-77) comprises three alpha helices and a beta hairpin, forming a core that occupies the concave DNA-binding surface of TBP. The TBP-binding surface of dTAF(II)230 markedly resembles the minor groove surface of the partially unwound TATA box in the TBP-TATA complex. This protein mimicry of the TATA element surface provides the structural basis of the mechanism by which dTAF(II)230 negatively controls the TATA box-binding activity within the TFIID complex.

About this Structure

1TBA is a Protein complex structure of sequences from Drosophila melanogaster and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Solution structure of a TBP-TAF(II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP., Liu D, Ishima R, Tong KI, Bagby S, Kokubo T, Muhandiram DR, Kay LE, Nakatani Y, Ikura M, Cell. 1998 Sep 4;94(5):573-83. PMID:9741622 Page seeded by OCA on Sat May 3 09:45:33 2008

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