1tbg

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[[Image:1tbg.jpg|left|200px]]
[[Image:1tbg.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbg OCA], [http://www.ebi.ac.uk/pdbsum/1tbg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tbg RCSB]</span>
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'''BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN'''
'''BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN'''
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[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
[[Category: Sondek, J S.]]
[[Category: Sondek, J S.]]
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[[Category: complex (gtp-binding/transducer)]]
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[[Category: Eye]]
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[[Category: eye]]
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[[Category: Prenylation]]
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[[Category: prenylation]]
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[[Category: Transducer]]
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[[Category: transducer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:45:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:53:55 2008''
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Revision as of 06:45, 3 May 2008

Image:1tbg.jpg

Template:STRUCTURE 1tbg

BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN


Overview

Many signalling cascades use seven-helical transmembrane receptors coupled to heterotrimeric G proteins (G alpha beta gamma) to convert extracellular signals into intracellular responses. Upon nucleotide exchange catalysed by activated receptors, heterotrimers dissociate into GTP-bound G alpha subunits and G beta gamma dimers, either of which can modulate many downstream effectors. Here we use multiwavelength anomalous diffraction data to solve the crystal structure of the beta gamma dimer of the G protein transducin. The beta-subunit is primarily a seven-bladed beta-propeller that is partially encircled by an extended gamma-subunit. The beta-propeller, which contains seven structurally similar WD repeats, defines the stereochemistry of the WD repeat and the probable architecture of all WD-repeat-containing domains. The structure details interactions between G protein beta- and gamma-subunits and highlights regions implicated in effector modulation for the conserved family of G protein beta gamma dimers.

About this Structure

1TBG is a Protein complex structure of sequences from Bos taurus. The following page contains interesting information on the relation of 1TBG with [G Proteins]. Full crystallographic information is available from OCA.

Reference

Crystal structure of a G-protein beta gamma dimer at 2.1A resolution., Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB, Nature. 1996 Jan 25;379(6563):369-74. PMID:8552196 Page seeded by OCA on Sat May 3 09:45:58 2008

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