8v5p
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the C-terminal domain of the VZV gE ectodomain in complex with the Fab of human antibody 5A2== | |
| - | + | <StructureSection load='8v5p' size='340' side='right'caption='[[8v5p]], [[Resolution|resolution]] 4.33Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8v5p]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_3 Human alphaherpesvirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V5P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.33Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v5p OCA], [https://pdbe.org/8v5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v5p RCSB], [https://www.ebi.ac.uk/pdbsum/8v5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v5p ProSAT]</span></td></tr> |
| - | [[Category: Harshbarger | + | </table> |
| - | [[Category: Malito | + | == Function == |
| + | [https://www.uniprot.org/uniprot/A0A1B1JEP3_HHV3 A0A1B1JEP3_HHV3] In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.[ARBA:ARBA00025134] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human alphaherpesvirus 3]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Harshbarger W]] | ||
| + | [[Category: Malito E]] | ||
Current revision
Crystal Structure of the C-terminal domain of the VZV gE ectodomain in complex with the Fab of human antibody 5A2
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