8v5l
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the Varicella Zoster Virus (VZV) gI binding domain of glycoprotein E (gE) in complex with human Fab 1A2 and 1E12== | |
| - | + | <StructureSection load='8v5l' size='340' side='right'caption='[[8v5l]], [[Resolution|resolution]] 3.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8v5l]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_3 Human alphaherpesvirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V5L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.09Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v5l OCA], [https://pdbe.org/8v5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v5l RCSB], [https://www.ebi.ac.uk/pdbsum/8v5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v5l ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Harshbarger | + | == Function == |
| - | [[Category: Seraj | + | [https://www.uniprot.org/uniprot/Q77JX0_HHV3 Q77JX0_HHV3] In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.[ARBA:ARBA00025134] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human alphaherpesvirus 3]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Harshbarger W]] | ||
| + | [[Category: Holzapfel G]] | ||
| + | [[Category: Seraj N]] | ||
Current revision
Structure of the Varicella Zoster Virus (VZV) gI binding domain of glycoprotein E (gE) in complex with human Fab 1A2 and 1E12
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