1tco

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[[Image:1tco.gif|left|200px]]
[[Image:1tco.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1tco |SIZE=350|CAPTION= <scene name='initialview01'>1tco</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1tco", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=506:The+Fk506+Binding+Site+On+Fkbp12+(Subunit+C)+As+Well+As+...'>506</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FK5:8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN'>FK5</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1tco| PDB=1tco | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tco OCA], [http://www.ebi.ac.uk/pdbsum/1tco PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tco RCSB]</span>
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}}
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'''TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)'''
'''TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)'''
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[[Category: Sintchak, M D.]]
[[Category: Sintchak, M D.]]
[[Category: Thomson, J A.]]
[[Category: Thomson, J A.]]
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[[Category: complex (hydrolase/isomerase)]]
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[[Category: Immunosuppressant]]
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[[Category: immunosuppressant]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:48:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:54:18 2008''
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Revision as of 06:48, 3 May 2008

Image:1tco.gif

Template:STRUCTURE 1tco

TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)


Overview

The X-ray structure of the ternary complex of a calcineurin A fragment, calcineurin B, FKBP12, and the immunosuppressant drug FK506 (also known as tacrolimus) has been determined at 2.5 A resolution, providing a description of how FK506 functions at the atomic level. In the structure, the FKBP12-FK506 binary complex does not contact the phosphatase active site on calcineurin A that is more than 10 A removed. Instead, FKBP12-FK506 is so positioned that it can inhibit the dephosphorylation of its macromolecular substrates by physically hindering their approach to the active site. The ternary complex described here represents the three-dimensional structure of a Ser/Thr protein phosphatase and provides a structural basis for understanding calcineurin inhibition by FKBP12-FK506.

About this Structure

1TCO is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex., Griffith JP, Kim JL, Kim EE, Sintchak MD, Thomson JA, Fitzgibbon MJ, Fleming MA, Caron PR, Hsiao K, Navia MA, Cell. 1995 Aug 11;82(3):507-22. PMID:7543369 Page seeded by OCA on Sat May 3 09:48:00 2008

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OCA

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