2q3f
From Proteopedia
(Difference between revisions)
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<StructureSection load='2q3f' size='340' side='right'caption='[[2q3f]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='2q3f' size='340' side='right'caption='[[2q3f]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2q3f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2q3f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q3F FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | < | + | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3f OCA], [https://pdbe.org/2q3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3f RCSB], [https://www.ebi.ac.uk/pdbsum/2q3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3f ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3f OCA], [https://pdbe.org/2q3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3f RCSB], [https://www.ebi.ac.uk/pdbsum/2q3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3f ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/RRAGD_HUMAN RRAGD_HUMAN] Has guanine nucleotide-binding activity but lacks intrinsic GTPase activity. Probably required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.<ref>PMID:20381137</ref> <ref>PMID:11073942</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q3f_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q3f_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Bochkarev A]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Keefe | + | [[Category: Keefe LJ]] |
| - | [[Category: Landry | + | [[Category: Landry R]] |
| - | [[Category: Mulichak | + | [[Category: Mulichak AM]] |
| - | [[Category: Nedyalkova | + | [[Category: Nedyalkova L]] |
| - | [[Category: Park | + | [[Category: Park H]] |
| - | [[Category: Rabeh | + | [[Category: Rabeh WM]] |
| - | + | [[Category: Sundstrom M]] | |
| - | [[Category: Sundstrom | + | [[Category: Tempel W]] |
| - | [[Category: Tempel | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | |
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Current revision
X-ray crystal structure of putative human Ras-related GTP binding D in complex with GMPPNP
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bochkarev A | Edwards AM | Keefe LJ | Landry R | Mulichak AM | Nedyalkova L | Park H | Rabeh WM | Sundstrom M | Tempel W | Weigelt J
