2w2r

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Current revision (07:48, 9 October 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2w2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vesicular_stomatitis_virus Vesicular stomatitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W2R FirstGlance]. <br>
<table><tr><td colspan='2'>[[2w2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vesicular_stomatitis_virus Vesicular stomatitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W2R FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w2s|2w2s]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2r OCA], [https://pdbe.org/2w2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2r RCSB], [https://www.ebi.ac.uk/pdbsum/2w2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2r OCA], [https://pdbe.org/2w2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2r RCSB], [https://www.ebi.ac.uk/pdbsum/2w2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2r ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MATRX_VSNJO MATRX_VSNJO] Plays a major role in assembly and budding of virion. Condensates the ribonucleocapsid core during virus assembly. Shut off cellular transcription by inhibiting mRNA nuclear export through direct interaction with host RAE1-NUP98 complex. This shutoff presumably inhibits interferon signaling and thus establishment of antiviral state in virus infected cells. Induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2r_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Vesicular stomatitis virus]]
[[Category: Vesicular stomatitis virus]]
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[[Category: Assenberg, R]]
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[[Category: Assenberg R]]
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[[Category: Bourhy, H]]
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[[Category: Bourhy H]]
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[[Category: Delmas, O]]
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[[Category: Delmas O]]
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[[Category: Gholami, A]]
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[[Category: Gholami A]]
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[[Category: Graham, S C]]
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[[Category: Graham SC]]
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[[Category: Grimes, J M]]
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[[Category: Grimes JM]]
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[[Category: Owens, R J]]
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[[Category: Owens RJ]]
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[[Category: Stuart, D I]]
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[[Category: Stuart DI]]
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[[Category: Talbi, C]]
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[[Category: Talbi C]]
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[[Category: Verma, A]]
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[[Category: Verma A]]
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[[Category: Matrix protein]]
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[[Category: Polymer]]
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[[Category: Viral assembly]]
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[[Category: Viral morphogenesis]]
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[[Category: Viral protein]]
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[[Category: Vsv]]
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Current revision

Structure of the vesicular stomatitis virus matrix protein

PDB ID 2w2r

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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