3s34
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s34 OCA], [https://pdbe.org/3s34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s34 RCSB], [https://www.ebi.ac.uk/pdbsum/3s34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s34 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s34 OCA], [https://pdbe.org/3s34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s34 RCSB], [https://www.ebi.ac.uk/pdbsum/3s34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s34 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The anti-VEGF receptor 2 antibody IMC-1121B is a promising antiangiogenic drug being tested for treatment of breast and gastric cancer. We have determined the structure of the 1121B Fab fragment in complex with domain 3 of VEGFR2, as well as the structure of a different neutralizing anti-VEGFR2 antibody, 6.64, also in complex with VEGFR2 domain 3. The two Fab fragments bind at opposite ends of VEGFR2 domain 3; 1121B directly blocks VEGF binding, whereas 6.64 may prevent receptor dimerization by perturbing the domain 3:domain 4 interface. Mutagenesis reveals that residues essential for VEGF, 1121B, and 6.64 binding are nonoverlapping among the three contact patches. | ||
| + | |||
| + | The Structural Basis for the Function of Two Anti-VEGF Receptor 2 Antibodies.,Franklin MC, Navarro EC, Wang Y, Patel S, Singh P, Zhang Y, Persaud K, Bari A, Griffith H, Shen L, Balderes P, Kussie P Structure. 2011 Aug 10;19(8):1097-107. PMID:21827946<ref>PMID:21827946</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 3s34" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Structure of the 1121B Fab fragment
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