6bdu
From Proteopedia
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<StructureSection load='6bdu' size='340' side='right'caption='[[6bdu]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='6bdu' size='340' side='right'caption='[[6bdu]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6bdu]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6bdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BDU FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bdu OCA], [https://pdbe.org/6bdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bdu RCSB], [https://www.ebi.ac.uk/pdbsum/6bdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bdu ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PPRA_DEIRA PPRA_DEIRA] dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end-joining (NHEJ) pathway for the repair of radiation-induced DNA double-strands breaks. Cannot bind to dsDNA without strand breaks or single-stranded DNA.<ref>PMID:15454524</ref> <ref>PMID:15458422</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Deinococcus radiodurans R1]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Czerwinski | + | [[Category: Czerwinski M]] |
| - | [[Category: Junop | + | [[Category: Junop MS]] |
| - | [[Category: Szabla | + | [[Category: Szabla R]] |
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Current revision
Crystal structure of PprA from Deinococcus radiodurans
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