6wt4

==Structure of a bacterial STING receptor from Flavobacteriaceae sp. in complex with 3',3'-cGAMP==

<table><tr><td colspan='2'>[[6wt4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Flavobacteriaceae Flavobacteriaceae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WT4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WT4 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4BW:2-AMINO-9-[(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-9-(6-AMINO-9H-PURIN-9-YL)-3,5,10,12-TETRAHYDROXY-5,12-DIOXIDOOCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECIN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE'>4BW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wt4 OCA], [http://pdbe.org/6wt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wt4 RCSB], [http://www.ebi.ac.uk/pdbsum/6wt4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wt4 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic dinucleotides released during bacterial infection and endogenous cyclic GMP-AMP signalling during viral infection and antitumour immunity(1-5). STING shares no structural homology with other known signalling proteins(6-9), limiting functional analysis and preventing explanation of the origin of cyclic dinucleotide signalling in mammalian innate immunity. Here we discover functional STING homologues encoded within prokaryotic defence islands and reveal a conserved mechanism of signal activation. Crystal structures of bacterial STING define a minimal homodimeric scaffold that selectively responds to c-di-GMP synthesized by a neighbouring cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzyme. Bacterial STING domains couple cyclic dinucleotide recognition with protein filament formation to drive TIR effector domain oligomerization and rapid NAD(+) cleavage. We reconstruct the evolutionary events following acquisition of STING into metazoan innate immunity and determine the structure of a full-length TIR-STING fusion from the Pacific oyster Crassostrea gigas. Comparative structural analysis demonstrates how metazoan-specific additions to the core STING scaffold enabled a switch from direct effector function to regulation of antiviral transcription. Together, our results explain the mechanism of STING-dependent signalling and reveal conservation of a functional cGAS-STING pathway in prokaryotic bacteriophage defence.

 

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== References ==

[[Category: Flavobacteriaceae]]

[[Category: Govande, A A]]

[[Category: Keszei, A F.A]]

[[Category: Kranzusch, P J]]

[[Category: Lowey, B]]

[[Category: Millman, A]]

[[Category: Morehouse, B R]]

[[Category: Ofir, G]]

[[Category: Shao, S]]

[[Category: Sorek, R]]

[[Category: Immune system]]