7liv
From Proteopedia
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| - | ==== | + | ==Structure of human transfer RNA visualized in the cytomegalovirus, a DNA virus== |
| - | <StructureSection load='7liv' size='340' side='right'caption='[[7liv]]' scene=''> | + | <StructureSection load='7liv' size='340' side='right'caption='[[7liv]], [[Resolution|resolution]] 3.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7liv]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LIV FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7liv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7liv OCA], [https://pdbe.org/7liv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7liv RCSB], [https://www.ebi.ac.uk/pdbsum/7liv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7liv ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7liv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7liv OCA], [https://pdbe.org/7liv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7liv RCSB], [https://www.ebi.ac.uk/pdbsum/7liv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7liv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Under the Baltimore nucleic acid-based virus classification scheme, the herpesvirus human cytomegalovirus (HCMV) is a Class I virus, meaning that it contains a double-stranded DNA genome-and no RNA. Here, we report sub-particle cryoEM reconstructions of HCMV virions at 2.9 A resolution revealing structures resembling non-coding transfer RNAs (tRNAs) associated with the virion's capsid-bound tegument protein, pp150. Through deep sequencing, we show that these RNA sequences match human tRNAs, and we built atomic models using the most abundant tRNA species. Based on our models, tRNA recruitment is mediated by the electrostatic interactions between tRNA phosphate groups and the helix-loop-helix motif of HCMV pp150. The specificity of these interactions may explain the absence of such tRNA densities in murine cytomegalovirus and other human herpesviruses. | ||
| + | |||
| + | Structure of human cytomegalovirus virion reveals host tRNA binding to capsid-associated tegument protein pp150.,Liu YT, Strugatsky D, Liu W, Zhou ZH Nat Commun. 2021 Sep 17;12(1):5513. doi: 10.1038/s41467-021-25791-1. PMID:34535641<ref>PMID:34535641</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7liv" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human herpesvirus 5 strain AD169]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Liu W]] |
| + | [[Category: Liu YT]] | ||
| + | [[Category: Strugatsky D]] | ||
| + | [[Category: Zhou ZH]] | ||
Current revision
Structure of human transfer RNA visualized in the cytomegalovirus, a DNA virus
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