7lvt

<table><tr><td colspan='2'>[[7lvt]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LVT FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lvt OCA], [https://pdbe.org/7lvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lvt RCSB], [https://www.ebi.ac.uk/pdbsum/7lvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lvt ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The kainate receptors (KARs) are members of the ionotropic glutamate receptor family and assemble into tetramers from a pool of five subunit types (GluK1-5). Each subunit confers distinct functional properties to a receptor, but the compositional and stoichiometric diversity of KAR tetramers is not well understood. To address this, we first solve the structure of the GluK1 homomer, which enables a systematic assessment of structural compatibility among KAR subunits. Next, we analyze single-cell RNA sequencing data, which reveal extreme diversity in the combinations of two or more KAR subunits co-expressed within the same cell. We then investigate the composition of individual receptor complexes using single-molecule fluorescence techniques and find that di-heteromers assembled from GluK1, GluK2, or GluK3 can form with all possible stoichiometries, while GluK1/K5, GluK2/K5, and GluK3/K5 can form 3:1 or 2:2 complexes. Finally, using three-color single-molecule imaging, we discover that KARs can form tri- and tetra-heteromers.

 

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== References ==

[[Category: Meyerson, J R]]

[[Category: Selvakumar, P]]

[[Category: Membrane protein]]