1tf5
From Proteopedia
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[[Image:1tf5.jpg|left|200px]] | [[Image:1tf5.jpg|left|200px]] | ||
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'''Crystal structure of SecA in an open conformation from Bacillus Subtilis''' | '''Crystal structure of SecA in an open conformation from Bacillus Subtilis''' | ||
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[[Category: Osborne, A R.]] | [[Category: Osborne, A R.]] | ||
[[Category: Rapoport, T A.]] | [[Category: Rapoport, T A.]] | ||
| - | [[Category: | + | [[Category: Atpase]] |
| - | [[Category: | + | [[Category: Helicase]] |
| - | [[Category: | + | [[Category: Secretion]] |
| - | [[Category: | + | [[Category: Translocation]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:52:42 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:52, 3 May 2008
Crystal structure of SecA in an open conformation from Bacillus Subtilis
Overview
The ATPase SecA mediates the posttranslational translocation of a wide range of polypeptide substrates through the SecY channel in the cytoplasmic membrane of bacteria. We have determined the crystal structure of a monomeric form of Bacillus subtilis SecA at a 2.2-A resolution. A comparison with the previously determined structures of SecA reveals a nucleotide-independent, large conformational change that opens a deep groove similar to that in other proteins that interact with diverse polypeptides. We propose that the open form of SecA represents an activated state.
About this Structure
1TF5 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
A large conformational change of the translocation ATPase SecA., Osborne AR, Clemons WM Jr, Rapoport TA, Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10937-42. Epub 2004 Jul 15. PMID:15256599 Page seeded by OCA on Sat May 3 09:52:42 2008
