1tf6

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[[Image:1tf6.jpg|left|200px]]
[[Image:1tf6.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1tf6 |SIZE=350|CAPTION= <scene name='initialview01'>1tf6</scene>, resolution 3.100&Aring;
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The line below this paragraph, containing "STRUCTURE_1tf6", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AN1:Zn-Binding+Site'>AN1</scene>, <scene name='pdbsite=AN2:Zn-Binding+Site'>AN2</scene>, <scene name='pdbsite=AN3:Zn-Binding+Site'>AN3</scene>, <scene name='pdbsite=AN4:Zn-Binding+Site'>AN4</scene>, <scene name='pdbsite=AN5:Zn-Binding+Site'>AN5</scene>, <scene name='pdbsite=AN6:Zn-Binding+Site'>AN6</scene>, <scene name='pdbsite=DN1:Zn-Binding+Site'>DN1</scene>, <scene name='pdbsite=DN2:Zn-Binding+Site'>DN2</scene>, <scene name='pdbsite=DN3:Zn-Binding+Site'>DN3</scene>, <scene name='pdbsite=DN4:Zn-Binding+Site'>DN4</scene>, <scene name='pdbsite=DN5:Zn-Binding+Site'>DN5</scene> and <scene name='pdbsite=DN6:&#39;Zn-Binding'>DN6</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1tf6| PDB=1tf6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf6 OCA], [http://www.ebi.ac.uk/pdbsum/1tf6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tf6 RCSB]</span>
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}}
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'''CO-CRYSTAL STRUCTURE OF XENOPUS TFIIIA ZINC FINGER DOMAIN BOUND TO THE 5S RIBOSOMAL RNA GENE INTERNAL CONTROL REGION'''
'''CO-CRYSTAL STRUCTURE OF XENOPUS TFIIIA ZINC FINGER DOMAIN BOUND TO THE 5S RIBOSOMAL RNA GENE INTERNAL CONTROL REGION'''
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[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]
[[Category: Nolte, R T.]]
[[Category: Nolte, R T.]]
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[[Category: complex (transcription regulation/dna)]]
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[[Category: Rna polymerase iii]]
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[[Category: rna polymerase iii]]
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[[Category: Transcription initiation]]
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[[Category: transcription initiation]]
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[[Category: Zinc finger protein]]
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[[Category: zinc finger protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:52:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:55:12 2008''
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Revision as of 06:52, 3 May 2008

Image:1tf6.jpg


PDB ID 1tf6

Drag the structure with the mouse to rotate
1tf6, resolution 3.10Å ()
Ligands:
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



CO-CRYSTAL STRUCTURE OF XENOPUS TFIIIA ZINC FINGER DOMAIN BOUND TO THE 5S RIBOSOMAL RNA GENE INTERNAL CONTROL REGION


Overview

The crystal structure of the six NH2-terminal zinc fingers of Xenopus laevis transcription factor IIIA (TFIIIA) bound with 31 bp of the 5S rRNA gene promoter has been determined at 3.1 A resolution. Individual zinc fingers are positioned differently in the major groove and across the minor groove of DNA to span the entire length of the duplex. These results show how TFIIIA can recognize several separated DNA sequences by using fewer fingers than necessary for continuous winding in the major groove.

About this Structure

1TF6 is a Single protein structure of sequence from Xenopus laevis. The following page contains interesting information on the relation of 1TF6 with [Zinc Fingers]. Full crystallographic information is available from OCA.

Reference

Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex., Nolte RT, Conlin RM, Harrison SC, Brown RS, Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2938-43. PMID:9501194 Page seeded by OCA on Sat May 3 09:52:47 2008

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