7v6o

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v6o OCA], [https://pdbe.org/7v6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v6o RCSB], [https://www.ebi.ac.uk/pdbsum/7v6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v6o ProSAT]</span></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/K0BRG7_MERS K0BRG7_MERS]] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]