7xwg

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Current revision (09:42, 9 October 2024) (edit) (undo)
 
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xwg OCA], [https://pdbe.org/7xwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xwg RCSB], [https://www.ebi.ac.uk/pdbsum/7xwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xwg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xwg OCA], [https://pdbe.org/7xwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xwg RCSB], [https://www.ebi.ac.uk/pdbsum/7xwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xwg ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRT6_ARATH PRT6_ARATH] Ubiquitin protein ligase which is a component of the N-end rule pathway with arginine specificity, and functions with the arginyltransferases ATE1 and ATE2. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:17572409, PubMed:19255443, PubMed:19620738, PubMed:22020282). Does not participate in degradation of proteins with N-terminal Phe or Leu (PubMed:17572409). The N-end rule pathway regulates seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination (PubMed:19255443). The N-end rule pathway regulates various aspects of leaf and shoot development (PubMed:19620738). Involved in the ubiquitination and subsequent degradation of RAP2-12, an activator of hypoxic gene expression. The ubiquitination occurs after the N-arginylation of RAP2-12 by ATE1 or ATE2 under aerobic conditions (PubMed:22020282). The end-rule pathway plays a role in regulating the timing and amplitude of the immune response following infection with the bacterial pathogen Pseudomonas syringae pv tomato (PubMed:27173012, PubMed:30117535). Regulates the biosynthesis of plant-defense metabolites such as glucosinolates, and the biosynthesis and response to the phytohormone jasmonate (JA), which plays a key role in plant immunity (PubMed:27173012). Controls the expression of specific defense-response genes, activates the synthesis pathway for the phytoalexin camalexin, and influences basal resistance to the hemibiotroph pathogen Pseudomonas syringae pv tomato (PubMed:30117535). Coordinates the mobilization of seed storage reserves and regulates the abundance and activities of several proteases following seed germination (PubMed:29168982).<ref>PMID:17572409</ref> <ref>PMID:19255443</ref> <ref>PMID:19620738</ref> <ref>PMID:22020282</ref> <ref>PMID:27173012</ref> <ref>PMID:29168982</ref> <ref>PMID:30117535</ref>
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==See Also==
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== References ==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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<references/>
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</StructureSection>
</StructureSection>

Current revision

RSGSGG-AtPRT6 UBR box

PDB ID 7xwg

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