8rqf

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Current revision (09:59, 9 October 2024) (edit) (undo)
 
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<table><tr><td colspan='2'>[[8rqf]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Hepatitis_B_virus_genotype_C Hepatitis B virus genotype C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RQF FirstGlance]. <br>
<table><tr><td colspan='2'>[[8rqf]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Hepatitis_B_virus_genotype_C Hepatitis B virus genotype C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RQF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.41&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.41&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BJU:N-tetradecanoylglycine'>BJU</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BJU:2-(tetradecanoylamino)ethanoic+acid'>BJU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rqf OCA], [https://pdbe.org/8rqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rqf RCSB], [https://www.ebi.ac.uk/pdbsum/8rqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rqf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rqf OCA], [https://pdbe.org/8rqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rqf RCSB], [https://www.ebi.ac.uk/pdbsum/8rqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rqf ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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<div style="background-color:#fffaf0;">
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[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
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== Publication Abstract from PubMed ==
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== Function ==
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Cellular entry of the hepatitis B and D viruses (HBV/HDV) requires binding of the viral surface polypeptide preS1 to the hepatobiliary transporter Na(+)-taurocholate co-transporting polypeptide (NTCP). This interaction can be blocked by bulevirtide (BLV, formerly Myrcludex B), a preS1 derivative and approved drug for treating HDV infection. Here, to elucidate the basis of this inhibitory function, we determined a cryo-EM structure of BLV-bound human NTCP. BLV forms two domains, a plug lodged in the bile salt transport tunnel of NTCP and a string that covers the receptor's extracellular surface. The N-terminally attached myristoyl group of BLV interacts with the lipid-exposed surface of NTCP. Our structure reveals how BLV inhibits bile salt transport, rationalizes NTCP mutations that decrease the risk of HBV/HDV infection, and provides a basis for understanding the host specificity of HBV/HDV. Our results provide opportunities for structure-guided development of inhibitors that target HBV/HDV docking to NTCP.
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[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799).<ref>PMID:14660639</ref> <ref>PMID:24867799</ref> (Microbial infection) Acts as a receptor for hepatitis B virus.<ref>PMID:23150796</ref>
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Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP.,Liu H, Zakrzewicz D, Nosol K, Irobalieva RN, Mukherjee S, Bang-Sorensen R, Goldmann N, Kunz S, Rossi L, Kossiakoff AA, Urban S, Glebe D, Geyer J, Locher KP Nat Commun. 2024 Mar 20;15(1):2476. doi: 10.1038/s41467-024-46706-w. PMID:38509088<ref>PMID:38509088</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 8rqf" style="background-color:#fffaf0;"></div>
== References ==
== References ==
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<references/>

Current revision

Cryo-EM structure of human NTCP-Bulevirtide complex

PDB ID 8rqf

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