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8xmn

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Current revision (10:04, 9 October 2024) (edit) (undo)
 
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xmn OCA], [https://pdbe.org/8xmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xmn RCSB], [https://www.ebi.ac.uk/pdbsum/8xmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xmn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xmn OCA], [https://pdbe.org/8xmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xmn RCSB], [https://www.ebi.ac.uk/pdbsum/8xmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xmn ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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<div style="background-color:#fffaf0;">
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[https://www.uniprot.org/uniprot/SCN9A_HUMAN SCN9A_HUMAN] Channelopathy-associated congenital insensitivity to pain;Dravet syndrome;Primary erythromelalgia;Sodium channelopathy-related small fiber neuropathy;Generalized epilepsy with febrile seizures-plus;Hereditary sensory and autonomic neuropathy type 2;Paroxysmal extreme pain disorder;Erythromelalgia. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Publication Abstract from PubMed ==
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== Function ==
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Voltage-gated sodium channels (Na(v)) undergo conformational shifts in response to membrane potential changes, a mechanism known as the electromechanical coupling. To delineate the structure-function relationship of human Na(v) channels, we have performed systematic structural analysis using human Na(v)1.7 as a prototype. Guided by the structural differences between wild-type (WT) Na(v)1.7 and an eleven mutation-containing variant, designated Na(v)1.7-M11, we generated three additional intermediate mutants and solved their structures at overall resolutions of 2.9-3.4 A. The mutant with nine-point mutations in the pore domain (PD), named Na(v)1.7-M9, has a reduced cavity volume and a sealed gate, with all voltage-sensing domains (VSDs) remaining up. Structural comparison of WT and Na(v)1.7-M9 pinpoints two residues that may be critical to the tightening of the PD. However, the variant containing these two mutations, Na(v)1.7-M2, or even in combination with two additional mutations in the VSDs, named Na(v)1.7-M4, failed to tighten the PD. Our structural analysis reveals a tendency of PD contraction correlated with the right shift of the static inactivation I-V curves. We predict that the channel in the resting state should have a "tight" PD with down VSDs.
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[https://www.uniprot.org/uniprot/SCN9A_HUMAN SCN9A_HUMAN] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).<ref>PMID:15178348</ref> <ref>PMID:15385606</ref> <ref>PMID:16988069</ref> <ref>PMID:17145499</ref> <ref>PMID:17167479</ref> <ref>PMID:19369487</ref> <ref>PMID:24311784</ref> <ref>PMID:25240195</ref> <ref>PMID:26680203</ref> <ref>PMID:7720699</ref>
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Dissection of the structure-function relationship of Na(v) channels.,Li Z, Wu Q, Huang G, Jin X, Li J, Pan X, Yan N Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2322899121. doi: , 10.1073/pnas.2322899121. Epub 2024 Feb 21. PMID:38381792<ref>PMID:38381792</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 8xmn" style="background-color:#fffaf0;"></div>
== References ==
== References ==
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<references/>

Current revision

Voltage-gated sodium channel Nav1.7 variant M2

PDB ID 8xmn

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