8uf8
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of alpha-Klotho== | |
| - | + | <StructureSection load='8uf8' size='340' side='right'caption='[[8uf8]], [[Resolution|resolution]] 6.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8uf8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UF8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uf8 OCA], [https://pdbe.org/8uf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uf8 RCSB], [https://www.ebi.ac.uk/pdbsum/8uf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uf8 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/KLOT_HUMAN KLOT_HUMAN] Familial tumoral calcinosis. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KLOT_HUMAN KLOT_HUMAN] May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gakhar L]] | ||
| + | [[Category: Huang CL]] | ||
| + | [[Category: Mohammad A]] | ||
| + | [[Category: Schnicker NJ]] | ||
| + | [[Category: Xu Z]] | ||
Current revision
Cryo-EM structure of alpha-Klotho
| |||||||||||
Categories: Homo sapiens | Large Structures | Gakhar L | Huang CL | Mohammad A | Schnicker NJ | Xu Z
