8uf9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==EcDsbA in complex with 2-benzyl-4-phenylthiazole-5-carboxylic acid== | |
| - | + | <StructureSection load='8uf9' size='340' side='right'caption='[[8uf9]], [[Resolution|resolution]] 2.16Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8uf9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UF9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=W9H:4-phenyl-2-(phenylmethyl)-1,3-thiazole-5-carboxylic+acid'>W9H</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uf9 OCA], [https://pdbe.org/8uf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uf9 RCSB], [https://www.ebi.ac.uk/pdbsum/8uf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uf9 ProSAT]</span></td></tr> |
| - | [[Category: Heras | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Heras B]] | ||
| + | [[Category: Wang G]] | ||
Current revision
EcDsbA in complex with 2-benzyl-4-phenylthiazole-5-carboxylic acid
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