8wqq

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Current revision (04:15, 17 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8wqq is ON HOLD until Paper Publication
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==Proteomics study reveals that ASFV g5Rp protein interacts with eukaryotic translation initiation factor 5A and may regulate host translation==
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<StructureSection load='8wqq' size='340' side='right'caption='[[8wqq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors: Liang, R.Y., Xu, C.M., Zhao, X.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8wqq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ASFV-like_virus_WU ASFV-like virus WU]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WQQ FirstGlance]. <br>
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Description: Proteomics study reveals that ASFV g5Rp protein interacts with eukaryotic translation initiation factor 5A and may regulate host translation
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wqq OCA], [https://pdbe.org/8wqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wqq RCSB], [https://www.ebi.ac.uk/pdbsum/8wqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wqq ProSAT]</span></td></tr>
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[[Category: Xu, C.M]]
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</table>
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[[Category: Liang, R.Y]]
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== Function ==
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[[Category: Zhao, X.M]]
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[https://www.uniprot.org/uniprot/DIPP_ASFB7 DIPP_ASFB7] Decapping enzyme required for the removal of the 5'-end m7GpppN cap tethered to viral and host mRNAs to allow their decay in cells (PubMed:19695654). May therefore accelerate viral and cellular mRNA turnover to eliminate competing host mRNAs and allow stage-specific synthesis of viral proteins. Acceleration of the turnover of cellular transcripts may even promote the shutoff of host protein synthesis (PubMed:29021398). In addition to the mRNA cap, g5R also efficiently hydrolyzes diphosphoinositol polyphosphates. Down-regulation of the level of PP-InsP5 (diphosphoinositol pentakisphosphate) may play a role in viral manipulation of the cellular secretory pathway, a step necessary for the formation of virions (PubMed:11773415). Binds viral and cellular poly(A) mRNAs, thereby decreasing both types of mRNAs (PubMed:19695654, PubMed:29021398).<ref>PMID:11773415</ref> <ref>PMID:19695654</ref> <ref>PMID:29021398</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: ASFV-like virus WU]]
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[[Category: Large Structures]]
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[[Category: Liang RY]]
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[[Category: Xu CM]]
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[[Category: Zhao XM]]

Current revision

Proteomics study reveals that ASFV g5Rp protein interacts with eukaryotic translation initiation factor 5A and may regulate host translation

PDB ID 8wqq

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OCA

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