9gp1

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m (Protected "9gp1" [edit=sysop:move=sysop])
Current revision (04:21, 17 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9gp1 is ON HOLD
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==Jumonji domain-containing protein 2A with crystallization epitope mutatios K330R:A334E==
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<StructureSection load='9gp1' size='340' side='right'caption='[[9gp1]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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Authors: Fairhead, M., Strain-Damerell, C., Ye, M., Mackinnon, S.R., Pinkas, D., MacLean, E.M., Koekemoer, L., Damerell, D., Krojer, T., Arrowsmith, C.H., Edwards, A., Bountra, C., Yue, W., Burgess-Brown, N., Marsden, B., von Delft, F., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9gp1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GP1 FirstGlance]. <br>
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Description: Jumonji domain-containing protein 2A with crystallization epitope mutatios K330R:A334E
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Strain-Damerell, C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gp1 OCA], [https://pdbe.org/9gp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gp1 RCSB], [https://www.ebi.ac.uk/pdbsum/9gp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gp1 ProSAT]</span></td></tr>
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[[Category: Arrowsmith, C.H]]
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</table>
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[[Category: Koekemoer, L]]
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== Function ==
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[[Category: Maclean, E.M]]
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[https://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>
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[[Category: Marsden, B]]
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== References ==
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[[Category: Fairhead, M]]
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<references/>
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[[Category: Burgess-Brown, N]]
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__TOC__
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[[Category: Krojer, T]]
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</StructureSection>
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[[Category: Ye, M]]
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[[Category: Homo sapiens]]
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[[Category: Von Delft, F]]
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[[Category: Large Structures]]
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[[Category: Pinkas, D]]
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[[Category: Arrowsmith CH]]
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[[Category: Mackinnon, S.R]]
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[[Category: Bountra C]]
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[[Category: Yue, W]]
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[[Category: Burgess-Brown N]]
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[[Category: Bountra, C]]
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[[Category: Damerell D]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Edwards A]]
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[[Category: Damerell, D]]
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[[Category: Fairhead M]]
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[[Category: Edwards, A]]
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[[Category: Koekemoer L]]
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[[Category: Krojer T]]
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[[Category: MacLean EM]]
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[[Category: Mackinnon SR]]
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[[Category: Marsden B]]
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[[Category: Pinkas D]]
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[[Category: Strain-Damerell C]]
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[[Category: Ye M]]
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[[Category: Yue W]]
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[[Category: Von Delft F]]

Current revision

Jumonji domain-containing protein 2A with crystallization epitope mutatios K330R:A334E

PDB ID 9gp1

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