9jdv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (04:21, 17 October 2024) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 9jdv is ON HOLD until Paper Publication
+
==Human URAT1 bound with Uric acid==
-
 
+
<StructureSection load='9jdv' size='340' side='right'caption='[[9jdv]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[9jdv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JDV FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.32&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=URC:URIC+ACID'>URC</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jdv OCA], [https://pdbe.org/9jdv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jdv RCSB], [https://www.ebi.ac.uk/pdbsum/9jdv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jdv ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/S22AC_HUMAN S22AC_HUMAN] Hereditary renal hypouricemia. The disease is caused by variants affecting the gene represented in this entry.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/S22AC_HUMAN S22AC_HUMAN] Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:12024214, PubMed:22194875, PubMed:35144162, PubMed:35462902). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:12024214, PubMed:22194875). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:12024214). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (PubMed:12024214). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption (PubMed:21350910). Orotate transport is Cl(-)-dependent (PubMed:21350910).<ref>PMID:12024214</ref> <ref>PMID:21350910</ref> <ref>PMID:22194875</ref> <ref>PMID:35144162</ref> <ref>PMID:35462902</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Wu C]]
 +
[[Category: Xu HE]]

Current revision

Human URAT1 bound with Uric acid

PDB ID 9jdv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9jdv"
Personal tools