1thf

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[[Image:1thf.jpg|left|200px]]
[[Image:1thf.jpg|left|200px]]
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{{Structure
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|PDB= 1thf |SIZE=350|CAPTION= <scene name='initialview01'>1thf</scene>, resolution 1.45&Aring;
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The line below this paragraph, containing "STRUCTURE_1thf", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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{{STRUCTURE_1thf| PDB=1thf | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1thf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1thf OCA], [http://www.ebi.ac.uk/pdbsum/1thf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1thf RCSB]</span>
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'''CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA'''
'''CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA'''
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[[Category: Lang, D A.]]
[[Category: Lang, D A.]]
[[Category: Wilmanns, M.]]
[[Category: Wilmanns, M.]]
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[[Category: histidine biosynthesis]]
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[[Category: Histidine biosynthesis]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: phosphate-binding site]]
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[[Category: Phosphate-binding site]]
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[[Category: thermophile]]
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[[Category: Thermophile]]
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[[Category: tim-barrel]]
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[[Category: Tim-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:57:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:56:03 2008''
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Revision as of 06:57, 3 May 2008

Image:1thf.jpg

Template:STRUCTURE 1thf

CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA


Overview

The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and structural analysis. The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins.

About this Structure

1THF is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion., Lang D, Thoma R, Henn-Sax M, Sterner R, Wilmanns M, Science. 2000 Sep 1;289(5484):1546-50. PMID:10968789 Page seeded by OCA on Sat May 3 09:57:09 2008

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