2ja4

From Proteopedia

(Difference between revisions)

Current revision

Crystal structure of CD5 domain III reveals the fold of a group B scavenger cysteine-rich receptor

Structural highlights

2ja4 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.21Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CD5_HUMAN May act as a receptor in regulating T-cell proliferation.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Scavenger receptor cysteine-rich (SRCR) domains are ancient protein modules widely found among cell surface and secreted proteins of the innate and adaptive immune system, where they mediate ligand binding. We have solved the crystal structure at 2.2 A of resolution of the SRCR CD5 domain III, a human lymphocyte receptor involved in the modulation of antigen specific receptor-mediated T cell activation and differentiation signals. The first structure of a member of a group B SRCR domain reveals the fold of this ancient protein module into a central core formed by two antiparallel beta-sheets and one alpha-helix, illustrating the conserved core at the protein level of genes coding for group A and B members of the SRCR superfamily. The novel SRCR group B structure permits the interpretation of site-directed mutagenesis data on the binding of activated leukocyte cell adhesion molecule (ALCAM/CD166) binding to CD6, a closely related lymphocyte receptor homologue to CD5.

Crystal structure of the third extracellular domain of CD5 reveals the fold of a group B scavenger cysteine-rich receptor domain.,Rodamilans B, Munoz IG, Bragado-Nilsson E, Sarrias MR, Padilla O, Blanco FJ, Lozano F, Montoya G J Biol Chem. 2007 Apr 27;282(17):12669-77. Epub 2007 Feb 23. PMID:17322294^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Rodamilans B, Munoz IG, Bragado-Nilsson E, Sarrias MR, Padilla O, Blanco FJ, Lozano F, Montoya G. Crystal structure of the third extracellular domain of CD5 reveals the fold of a group B scavenger cysteine-rich receptor domain. J Biol Chem. 2007 Apr 27;282(17):12669-77. Epub 2007 Feb 23. PMID:17322294 doi:10.1074/jbc.M611699200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ja4"

@@ Line 3: / Line 3: @@
 <StructureSection load='2ja4' size='340' side='right'caption='[[2ja4]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ja4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JA4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ja4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JA4 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ja4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ja4 OCA], [https://pdbe.org/2ja4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ja4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ja4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ja4 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ja4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ja4 OCA], [https://pdbe.org/2ja4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ja4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ja4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ja4 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/CD5_HUMAN CD5_HUMAN]] May act as a receptor in regulating T-cell proliferation.
+[https://www.uniprot.org/uniprot/CD5_HUMAN CD5_HUMAN] May act as a receptor in regulating T-cell proliferation.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 13: / Line 14: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2ja4_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 31: / Line 32: @@
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Blanco, F J]]
+[[Category: Blanco FJ]]
-[[Category: Lozano, F]]
+[[Category: Lozano F]]
-[[Category: Montoya, G]]
+[[Category: Montoya G]]
-[[Category: Munoz, I G]]
+[[Category: Munoz IG]]
-[[Category: Rodamilans, B]]
+[[Category: Rodamilans B]]
-[[Category: Sarrias, M R]]
+[[Category: Sarrias MR]]
-[[Category: Cd5]]
-[[Category: Cd6]]
-[[Category: Glycoprotein]]
-[[Category: Immune system]]
-[[Category: Innate immunity]]
-[[Category: Membrane]]
-[[Category: Phosphorylation]]
-[[Category: Polymorphism]]
-[[Category: Srcr]]
-[[Category: Transmembrane]]

2ja4

From Proteopedia

Current revision

Crystal structure of CD5 domain III reveals the fold of a group B scavenger cysteine-rich receptor

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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