1tif

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[[Image:1tif.gif|left|200px]]
[[Image:1tif.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1tif |SIZE=350|CAPTION= <scene name='initialview01'>1tif</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1tif", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PBM:TRIMETHYL+LEAD+ION'>PBM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus])
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-->
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|DOMAIN=
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{{STRUCTURE_1tif| PDB=1tif | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tif OCA], [http://www.ebi.ac.uk/pdbsum/1tif PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tif RCSB]</span>
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}}
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'''TRANSLATION INITIATION FACTOR 3 N-TERMINAL DOMAIN'''
'''TRANSLATION INITIATION FACTOR 3 N-TERMINAL DOMAIN'''
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[[Category: Ramakrishnan, V.]]
[[Category: Ramakrishnan, V.]]
[[Category: Shu, F.]]
[[Category: Shu, F.]]
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[[Category: if3 n-terminal domain]]
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[[Category: If3 n-terminal domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:59:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:56:30 2008''
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Revision as of 06:59, 3 May 2008

Image:1tif.gif

Template:STRUCTURE 1tif

TRANSLATION INITIATION FACTOR 3 N-TERMINAL DOMAIN


Overview

The structures of the two domains of translational initiation factor IF3 from Bacillus stearothermophilus have been solved by X-ray crystallography using single wavelength anomalous scattering and multiwavelength anomalous diffraction. Each of the two domains has an alpha/beta topology, with an exposed beta-sheet that is reminiscent of several ribosomal and other RNA binding proteins. An alpha-helix that protrudes out from the body of the N-terminal domain towards the C-terminal domain suggests that IF3 consists of two RNA binding domains connected by an alpha-helix and that it may bridge two regions of the ribosome. This represents the first high resolution structural information on a translational initiation factor.

About this Structure

1TIF is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

X-ray crystallography shows that translational initiation factor IF3 consists of two compact alpha/beta domains linked by an alpha-helix., Biou V, Shu F, Ramakrishnan V, EMBO J. 1995 Aug 15;14(16):4056-64. PMID:7664745 Page seeded by OCA on Sat May 3 09:59:04 2008

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OCA

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