1tip

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[[Image:1tip.jpg|left|200px]]
[[Image:1tip.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1tip |SIZE=350|CAPTION= <scene name='initialview01'>1tip</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1tip", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=NEP:N1-PHOSPHONOHISTIDINE'>NEP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-2,6-bisphosphate_2-phosphatase Fructose-2,6-bisphosphate 2-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.46 3.1.3.46] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= A CODING REGION WHICH COVERS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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-->
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|DOMAIN=
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{{STRUCTURE_1tip| PDB=1tip | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tip OCA], [http://www.ebi.ac.uk/pdbsum/1tip PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tip RCSB]</span>
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}}
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'''THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE'''
'''THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE'''
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[[Category: Ogata, C M.]]
[[Category: Ogata, C M.]]
[[Category: Olson, T W.]]
[[Category: Olson, T W.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: multifunctional enzyme]]
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[[Category: Multifunctional enzyme]]
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[[Category: multigene family]]
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[[Category: Multigene family]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:59:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:56:35 2008''
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Revision as of 06:59, 3 May 2008

Image:1tip.jpg

Template:STRUCTURE 1tip

THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE


Overview

The crystal structure of the fructose-2,6-bisphosphatase domain trapped during the reaction reveal a phosphorylated His 258, and a water molecule immobilized by the product, fructose-6-phosphate. The geometry suggests that the dephosphorylation step requires prior removal of the product for an 'associative in-line' phosphoryl transfer to the catalytic water.

About this Structure

1TIP is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a trapped phosphoenzyme during a catalytic reaction., Lee YH, Olson TW, Ogata CM, Levitt DG, Banaszak LJ, Lange AJ, Nat Struct Biol. 1997 Aug;4(8):615-8. PMID:9253407 Page seeded by OCA on Sat May 3 09:59:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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