1tiv
From Proteopedia
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'''STRUCTURAL STUDIES OF HIV-1 TAT PROTEIN''' | '''STRUCTURAL STUDIES OF HIV-1 TAT PROTEIN''' | ||
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[[Category: Kraft, M.]] | [[Category: Kraft, M.]] | ||
[[Category: Roesch, P.]] | [[Category: Roesch, P.]] | ||
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Revision as of 07:00, 3 May 2008
STRUCTURAL STUDIES OF HIV-1 TAT PROTEIN
Overview
Tat (trans-activator) proteins are early RNA binding proteins regulating lentiviral transcription. These proteins are necessary components in the life cycle of all known lentiviruses, such as the human immunodeficiency viruses (HIV) or the equine infectious anemia virus (EIAV). Tat proteins are thus ideal targets for drugs intervening with lentiviral growth. The consensus RNA binding motif (TAR, trans-activation responsive element) of HIV-1 is well characterized. Structural features of the 86 amino acid HIV-1, Zaire 2 isolate (HV1Z2) Tat protein in solution were determined by two dimensional (2D) nuclear magnetic resonance (NMR) methods and molecular dynamics (MD) calculations. In general, sequence regions corresponded to structural domains of the protein. It exhibited a hydrophobic core of 16 amino acids and a glutamine-rich domain of 17 amino acids. Part of the NH2 terminus, Val4 to Pro14, was sandwiched between these domains. Two highly flexible domains corresponded to a cysteine-rich and a basic sequence region. The 16 amino acid sequence of the core region is strictly conserved among the known Tat proteins, and the three-dimensional fold of these amino acids of HV1Z2 Tat protein was highly similar to the structure of the corresponding EIAV Tat domain. HV1Z2 Tat protein contained a well defined COOH-terminal Arg-Gly-Asp (RGD) loop similar to the recently determined decorsin RGD loop.
About this Structure
1TIV is a Single protein structure of sequence from Human immunodeficiency virus. Full crystallographic information is available from OCA.
Reference
Structural studies of HIV-1 Tat protein., Bayer P, Kraft M, Ejchart A, Westendorp M, Frank R, Rosch P, J Mol Biol. 1995 Apr 7;247(4):529-35. PMID:7723010 Page seeded by OCA on Sat May 3 10:00:01 2008
