3qqi
From Proteopedia
(Difference between revisions)
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<StructureSection load='3qqi' size='340' side='right'caption='[[3qqi]], [[Resolution|resolution]] 1.65Å' scene=''> | <StructureSection load='3qqi' size='340' side='right'caption='[[3qqi]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3qqi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3qqi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Japan/305/1957(H2N2)) Influenza A virus (A/Japan/305/1957(H2N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QQI FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> |
- | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qqi OCA], [https://pdbe.org/3qqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qqi RCSB], [https://www.ebi.ac.uk/pdbsum/3qqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qqi ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qqi OCA], [https://pdbe.org/3qqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qqi RCSB], [https://www.ebi.ac.uk/pdbsum/3qqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qqi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
- | + | [https://www.uniprot.org/uniprot/C7S226_I57A0 C7S226_I57A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643] | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: I57a0]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Wilson | + | [[Category: Wilson IA]] |
- | [[Category: Xu | + | [[Category: Xu R]] |
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Current revision
Crystal structure of the HA1 receptor binding domain of H2 hemagglutinin
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