4kpe
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4kpe]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KPE FirstGlance]. <br> | <table><tr><td colspan='2'>[[4kpe]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KPE FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AF5:(7AR,8R)-8-AMINO-4-CYCLOPROPYL-12-FLUORO-1-OXO-4,7,7A,8,9,10-HEXAHYDRO-1H-PYRROLO[1,2 1,7]AZEPINO[2,3-H]QUINOLINE-2-CARBOXYLIC+ACID'>AF5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.43Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AF5:(7AR,8R)-8-AMINO-4-CYCLOPROPYL-12-FLUORO-1-OXO-4,7,7A,8,9,10-HEXAHYDRO-1H-PYRROLO[1,2 1,7]AZEPINO[2,3-H]QUINOLINE-2-CARBOXYLIC+ACID'>AF5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpe OCA], [https://pdbe.org/4kpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kpe RCSB], [https://www.ebi.ac.uk/pdbsum/4kpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kpe ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpe OCA], [https://pdbe.org/4kpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kpe RCSB], [https://www.ebi.ac.uk/pdbsum/4kpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kpe ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ | + | [https://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate
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