1tjy
From Proteopedia
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'''Crystal Structure of Salmonella typhimurium AI-2 receptor LsrB in complex with R-THMF''' | '''Crystal Structure of Salmonella typhimurium AI-2 receptor LsrB in complex with R-THMF''' | ||
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[[Category: Xavier, K B.]] | [[Category: Xavier, K B.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:02:28 2008'' | |
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Revision as of 07:02, 3 May 2008
Crystal Structure of Salmonella typhimurium AI-2 receptor LsrB in complex with R-THMF
Overview
Bacterial populations use cell-cell communication to coordinate community-wide regulation of processes such as biofilm formation, virulence, and bioluminescence. This phenomenon, termed quorum sensing, is mediated by small molecule signals known as autoinducers. While most autoinducers are species specific, autoinducer-2 (AI-2), first identified in the marine bacterium Vibrio harveyi, is produced and detected by many Gram-negative and Gram-positive bacteria. The crystal structure of the V. harveyi AI-2 signaling molecule bound to its receptor protein revealed an unusual furanosyl borate diester. Here, we present the crystal structure of a second AI-2 signal binding protein, LsrB from Salmonella typhimurium. We find that LsrB binds a chemically distinct form of the AI-2 signal, (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran (R-THMF), that lacks boron. Our results demonstrate that two different species of bacteria recognize two different forms of the autoinducer signal, both derived from 4,5-dihydroxy-2,3-pentanedione (DPD), and reveal new sophistication in the chemical lexicon used by bacteria in interspecies signaling.
About this Structure
1TJY is a Single protein structure of sequence from Salmonella typhimurium lt2. Full crystallographic information is available from OCA.
Reference
Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2., Miller ST, Xavier KB, Campagna SR, Taga ME, Semmelhack MF, Bassler BL, Hughson FM, Mol Cell. 2004 Sep 10;15(5):677-87. PMID:15350213 Page seeded by OCA on Sat May 3 10:02:28 2008
