5uz7

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Current revision (07:40, 17 October 2024) (edit) (undo)
 
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<SX load='5uz7' size='340' side='right' viewer='molstar' caption='[[5uz7]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
<SX load='5uz7' size='340' side='right' viewer='molstar' caption='[[5uz7]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uz7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UZ7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uz7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UZ7 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GNAS, GNAS1, GSP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CALCR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5uz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uz7 OCA], [http://pdbe.org/5uz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uz7 RCSB], [http://www.ebi.ac.uk/pdbsum/5uz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uz7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uz7 OCA], [https://pdbe.org/5uz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uz7 RCSB], [https://www.ebi.ac.uk/pdbsum/5uz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uz7 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN]] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref> [[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> [[http://www.uniprot.org/uniprot/CALCR_HUMAN CALCR_HUMAN]] This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
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[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Camelus glama]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baumeister, W]]
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[[Category: Baumeister W]]
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[[Category: Christopoulos, A]]
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[[Category: Christopoulos A]]
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[[Category: Christopoulos, G]]
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[[Category: Christopoulos G]]
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[[Category: Coudrat, T]]
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[[Category: Coudrat T]]
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[[Category: Danev, R]]
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[[Category: Danev R]]
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[[Category: Furness, S G.B]]
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[[Category: Furness SGB]]
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[[Category: Glukhova, A]]
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[[Category: Glukhova A]]
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[[Category: Khoshouei, M]]
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[[Category: Khoshouei M]]
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[[Category: Kobilka, B K]]
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[[Category: Kobilka BK]]
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[[Category: Liang, Y L]]
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[[Category: Liang YL]]
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[[Category: Miller, L J]]
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[[Category: Miller LJ]]
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[[Category: Radjainia, M]]
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[[Category: Radjainia M]]
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[[Category: Sexton, P M]]
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[[Category: Sexton PM]]
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[[Category: Skiniotis, G]]
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[[Category: Skiniotis G]]
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[[Category: Tarrasch, J]]
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[[Category: Tarrasch J]]
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[[Category: Thal, D M]]
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[[Category: Thal DM]]
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[[Category: Wootten, D]]
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[[Category: Wootten D]]
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[[Category: Zhang, Y]]
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[[Category: Zhang Y]]
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[[Category: Class b g protein-coupled receptor agonist-receptor-g protein ternary complex calcitonin receptor active-state g protein-coupled receptor]]
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[[Category: Signaling protein]]
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Current revision

Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex

5uz7, resolution 4.10Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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