5zkp
From Proteopedia
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<table><tr><td colspan='2'>[[5zkp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_vulgaris_str._Hildenborough Desulfovibrio vulgaris str. Hildenborough] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZKP FirstGlance]. <br> | <table><tr><td colspan='2'>[[5zkp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_vulgaris_str._Hildenborough Desulfovibrio vulgaris str. Hildenborough] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZKP FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> | ||
| - | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9ER: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9ER:~{N},~{N}-dimethyl-~{N}-(pyridin-3-ylmethyl)-~{N}-[4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl]ethane-1,2-diamine'>9ER</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zkp OCA], [https://pdbe.org/5zkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zkp RCSB], [https://www.ebi.ac.uk/pdbsum/5zkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zkp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zkp OCA], [https://pdbe.org/5zkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zkp RCSB], [https://www.ebi.ac.uk/pdbsum/5zkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zkp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/PTAFR_HUMAN PTAFR_HUMAN] Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.<ref>PMID:1281995</ref> <ref>PMID:1374385</ref> <ref>PMID:1656963</ref> <ref>PMID:1657923</ref> [https://www.uniprot.org/uniprot/ | + | [https://www.uniprot.org/uniprot/PTAFR_HUMAN PTAFR_HUMAN] Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.<ref>PMID:1281995</ref> <ref>PMID:1374385</ref> <ref>PMID:1656963</ref> <ref>PMID:1657923</ref> [https://www.uniprot.org/uniprot/FLAV_NITV2 FLAV_NITV2] Low-potential electron donor to a number of redox enzymes. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal structure of the human platelet-activating factor receptor in complex with SR 27417
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