1tkt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1tkt.jpg|left|200px]]
[[Image:1tkt.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1tkt |SIZE=350|CAPTION= <scene name='initialview01'>1tkt</scene>, resolution 2.60&Aring;
+
The line below this paragraph, containing "STRUCTURE_1tkt", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=H12:6-CHLORO-4-(CYCLOHEXYLOXY)-3-PROPYLQUINOLIN-2(1H)-ONE'>H12</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1tkt| PDB=1tkt | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tkt OCA], [http://www.ebi.ac.uk/pdbsum/1tkt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tkt RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318'''
'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318'''
Line 30: Line 27:
[[Category: Stammers, D K.]]
[[Category: Stammers, D K.]]
[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
-
[[Category: aid]]
+
[[Category: Aid]]
-
[[Category: drug design]]
+
[[Category: Drug design]]
-
[[Category: gw426318]]
+
[[Category: Gw426318]]
-
[[Category: hiv-1 reverse transcriptase]]
+
[[Category: Hiv-1 reverse transcriptase]]
-
[[Category: nnrti]]
+
[[Category: Nnrti]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:04:24 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:57:33 2008''
+

Revision as of 07:04, 3 May 2008

Image:1tkt.jpg

Template:STRUCTURE 1tkt

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318


Overview

We have used a structure-based approach to design a novel series of non-nucleoside inhibitors of HIV-1 RT (NNRTIs). Detailed analysis of a wide range of crystal structures of HIV-1 RT-NNRTI complexes together with data on drug resistance mutations has identified factors important for tight binding of inhibitors and resilience to mutations. Using this approach we have designed and synthesized a novel series of quinolone NNRTIs. Crystal structure analysis of four of these compounds in complexes with HIV-1 RT confirms the predicted binding modes. Members of this quinolone series retain high activity against the important resistance mutations in RT at Tyr181Cys and Leu100Ile.

About this Structure

1TKT is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1., Hopkins AL, Ren J, Milton J, Hazen RJ, Chan JH, Stuart DI, Stammers DK, J Med Chem. 2004 Nov 18;47(24):5912-22. PMID:15537346 Page seeded by OCA on Sat May 3 10:04:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tkt"
Personal tools