6huj
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6huj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6huj OCA], [https://pdbe.org/6huj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6huj RCSB], [https://www.ebi.ac.uk/pdbsum/6huj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6huj ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6huj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6huj OCA], [https://pdbe.org/6huj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6huj RCSB], [https://www.ebi.ac.uk/pdbsum/6huj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6huj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/GBRA1_HUMAN GBRA1_HUMAN] Juvenile myoclonic epilepsy;Childhood absence epilepsy;Dravet syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/GBRA1_BOVIN GBRA1_BOVIN] Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.<ref>PMID:3037384</ref> [https://www.uniprot.org/uniprot/GBRA1_HUMAN GBRA1_HUMAN] Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38.
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Categories: Bos taurus | Homo sapiens | Lama glama | Large Structures | Aricescu AR | Desai R | Jasenko Z | Karia D | Kotecha A | Laverty D | Malinauskas T | Masiulis S | Miller KW | Pardon E | Serna Martin I | Steyaert J | Uchanski T
