6iaa

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Current revision (08:02, 17 October 2024) (edit) (undo)
 
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<StructureSection load='6iaa' size='340' side='right'caption='[[6iaa]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<StructureSection load='6iaa' size='340' side='right'caption='[[6iaa]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6iaa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IAA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6iaa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IAA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6i9s|6i9s]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iaa OCA], [https://pdbe.org/6iaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iaa RCSB], [https://www.ebi.ac.uk/pdbsum/6iaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iaa ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ROBO2, KIAA1568 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iaa OCA], [http://pdbe.org/6iaa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iaa RCSB], [http://www.ebi.ac.uk/pdbsum/6iaa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iaa ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/ROBO2_HUMAN ROBO2_HUMAN]] Defects in ROBO2 are the cause of vesicoureteral reflux type 2 (VUR2) [MIM:[http://omim.org/entry/610878 610878]]. VUR is a complex, genetically heterogeneous developmental disorder characterized by the retrograde flow of urine from the bladder into the ureter and is associated with reflux nephropathy, the cause of 15% of end-stage renal disease in children and young adults.<ref>PMID:17357069</ref> Note=A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT-ROBO signaling in vitro.
 
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== Function ==
 
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[[http://www.uniprot.org/uniprot/ROBO2_HUMAN ROBO2_HUMAN]] Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Barak, R]]
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[[Category: Barak R]]
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[[Category: Isupov, N M]]
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[[Category: Isupov NM]]
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[[Category: Opatowsky, Y]]
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[[Category: Opatowsky Y]]
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[[Category: Axon guidance]]
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[[Category: Cell surface receptor]]
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[[Category: Robo]]
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[[Category: Signaling protein]]
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[[Category: Slit]]
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Current revision

hRobo2 ectodomain

PDB ID 6iaa

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