6nan

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Current revision (08:09, 17 October 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6nan]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ixodes_scapularis Ixodes scapularis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NAN FirstGlance]. <br>
<table><tr><td colspan='2'>[[6nan]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ixodes_scapularis Ixodes scapularis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NAN FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nan OCA], [https://pdbe.org/6nan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nan RCSB], [https://www.ebi.ac.uk/pdbsum/6nan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nan ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nan OCA], [https://pdbe.org/6nan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nan RCSB], [https://www.ebi.ac.uk/pdbsum/6nan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nan ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[https://www.uniprot.org/uniprot/Q964Q0_IXOSC Q964Q0_IXOSC]
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[https://www.uniprot.org/uniprot/IXOSP_IXOSC IXOSP_IXOSC] Anticoagulant protein that modulates blood feeding of ticks on vertebrate species (PubMed:16807644, PubMed:32394234). Inhibits activation of host blood coagulation factor X (F10) (PubMed:11986214, PubMed:18042685, PubMed:28734839). Inhibits activity of host coagulation factor VIIa-tissue factor (F7-F3) complex in a factor X/Xa-dependent manner (PubMed:11986214). Prevents interaction between host coagulation factor X and activated factor VIIIa (F8) (PubMed:18042685).<ref>PMID:11986214</ref> <ref>PMID:16807644</ref> <ref>PMID:18042685</ref> <ref>PMID:28734839</ref> <ref>PMID:32394234</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition

PDB ID 6nan

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