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| | <StructureSection load='6p4r' size='340' side='right'caption='[[6p4r]], [[Resolution|resolution]] 1.87Å' scene=''> | | <StructureSection load='6p4r' size='340' side='right'caption='[[6p4r]], [[Resolution|resolution]] 1.87Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6p4r]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhi_ct18 Salmonella enterica subsp. enterica serovar typhi ct18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P4R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6P4R FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6p4r]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhi_str._CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P4R FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87Å</td></tr> |
| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900046:6-sialyl-N-acetyllactosamine'>PRD_900046</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STY1891, t1107 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=220341 Salmonella enterica subsp. enterica serovar Typhi CT18])</td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p4r OCA], [https://pdbe.org/6p4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p4r RCSB], [https://www.ebi.ac.uk/pdbsum/6p4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p4r ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6p4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p4r OCA], [http://pdbe.org/6p4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p4r RCSB], [http://www.ebi.ac.uk/pdbsum/6p4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p4r ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q8Z6A3_SALTI Q8Z6A3_SALTI] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Salmonella enterica subsp. enterica serovar typhi ct18]] | + | [[Category: Salmonella enterica subsp. enterica serovar Typhi str. CT18]] |
| - | [[Category: Hillpot, E C]] | + | [[Category: Hillpot EC]] |
| - | [[Category: Milano, S K]] | + | [[Category: Milano SK]] |
| - | [[Category: Nguyen, T]] | + | [[Category: Nguyen T]] |
| - | [[Category: Song, J]] | + | [[Category: Song J]] |
| - | [[Category: Yang, Y A]] | + | [[Category: Yang YA]] |
| - | [[Category: Pltb]]
| + | |
| - | [[Category: Toxin]]
| + | |
| Structural highlights
Function
Q8Z6A3_SALTI
Publication Abstract from PubMed
Typhoidal and non-typhoidal Salmonelleae (NTS) cause typhoid fever and gastroenteritis, respectively, in humans. Salmonella typhoid toxin contributes to typhoid disease progression and chronic infection, but little is known about the role of its NTS ortholog. We found that typhoid toxin and its NTS ortholog induce different clinical presentations. The PltB subunit of each toxin exhibits different glycan-binding preferences that correlate with glycan expression profiles of host cells targeted by each bacterium at the primary infection or intoxication sites. Through co-crystal structures of PltB subunits bound to specific glycan receptor moieties, we show that they induce markedly different glycan-binding preferences and virulence outcomes. Furthermore, immunization with the NTS S. Javiana or its toxin offers cross-reactive protection against lethal-dose typhoid toxin challenge. Cumulatively, these results offer insights into the evolution of host adaptations in Salmonella AB toxins, their cell and tissue tropisms, and the design for improved typhoid vaccines and therapeutics.
Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence.,Lee S, Yang YA, Milano SK, Nguyen T, Ahn C, Sim JH, Thompson AJ, Hillpot EC, Yoo G, Paulson JC, Song J Cell Host Microbe. 2020 Jun 10;27(6):937-949.e6. doi: 10.1016/j.chom.2020.04.005., Epub 2020 May 11. PMID:32396840[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Lee S, Yang YA, Milano SK, Nguyen T, Ahn C, Sim JH, Thompson AJ, Hillpot EC, Yoo G, Paulson JC, Song J. Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence. Cell Host Microbe. 2020 Jun 10;27(6):937-949.e6. doi: 10.1016/j.chom.2020.04.005., Epub 2020 May 11. PMID:32396840 doi:http://dx.doi.org/10.1016/j.chom.2020.04.005
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