6s1j
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s1j OCA], [https://pdbe.org/6s1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s1j RCSB], [https://www.ebi.ac.uk/pdbsum/6s1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s1j ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s1j OCA], [https://pdbe.org/6s1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s1j RCSB], [https://www.ebi.ac.uk/pdbsum/6s1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s1j ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[https://omim.org/entry/614104 614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal Structure of DYRK1A with small molecule inhibitor
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