6uza

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Current revision (08:24, 17 October 2024) (edit) (undo)
 
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<StructureSection load='6uza' size='340' side='right'caption='[[6uza]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
<StructureSection load='6uza' size='340' side='right'caption='[[6uza]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6uza]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UZA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6uza]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UZA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R0G:4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile'>R0G</scene>, <scene name='pdbligand=S9Y:2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium'>S9Y</scene>, <scene name='pdbligand=SBJ:[(2~{S})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-octanoyloxy-propan-2-yl]+octadecanoate'>SBJ</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.08&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6uz8|6uz8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R0G:4-[[(1~{R},2~{R})-2-[(3~{R})-3-azanylpiperidin-1-yl]-2,3-dihydro-1~{H}-inden-1-yl]oxy]benzenecarbonitrile'>R0G</scene>, <scene name='pdbligand=S9Y:2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium'>S9Y</scene>, <scene name='pdbligand=SBJ:[(2~{S})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-octanoyloxy-propan-2-yl]+octadecanoate'>SBJ</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uza OCA], [http://pdbe.org/6uza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uza RCSB], [http://www.ebi.ac.uk/pdbsum/6uza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uza ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uza OCA], [https://pdbe.org/6uza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uza RCSB], [https://www.ebi.ac.uk/pdbsum/6uza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uza ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN]] Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN] Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN]] Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.<ref>PMID:19936226</ref> <ref>PMID:23291369</ref> <ref>PMID:26892346</ref>
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[https://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN] Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.<ref>PMID:19936226</ref> <ref>PMID:23291369</ref> <ref>PMID:26892346</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bai, Y]]
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[[Category: Bai Y]]
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[[Category: Chen, H]]
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[[Category: Chen H]]
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[[Category: Huang, X]]
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[[Category: Huang X]]
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[[Category: Yu, X]]
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[[Category: Yu X]]
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[[Category: Antagonist]]
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[[Category: Transport protein]]
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[[Category: Trp channel]]
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Current revision

Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473

PDB ID 6uza

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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