6wex
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wex OCA], [https://pdbe.org/6wex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wex RCSB], [https://www.ebi.ac.uk/pdbsum/6wex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wex ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wex OCA], [https://pdbe.org/6wex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wex RCSB], [https://www.ebi.ac.uk/pdbsum/6wex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wex ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/A0A0J9X245_9INFA A0A0J9X245_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H6 Hemagglutinin
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