6zk7

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Current revision (08:32, 17 October 2024) (edit) (undo)
 
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<StructureSection load='6zk7' size='340' side='right'caption='[[6zk7]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='6zk7' size='340' side='right'caption='[[6zk7]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6zk7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZK7 FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZK7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zk7 OCA], [https://pdbe.org/6zk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zk7 RCSB], [https://www.ebi.ac.uk/pdbsum/6zk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zk7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zk7 OCA], [https://pdbe.org/6zk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zk7 RCSB], [https://www.ebi.ac.uk/pdbsum/6zk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zk7 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[https://www.uniprot.org/uniprot/PYRD1_HUMAN PYRD1_HUMAN] The disease is caused by variants affecting the gene represented in this entry. A mutation in PYROXD1 is the cause of autosomal recessive limb-girdle muscular dystrophy. The affected individual with a homozygous recessive PYROXD1 mutation showed progressive muscle weakness with an onset at the age of 9 years. Initial symptoms included excessive falling while running, with slowly progressive weakness. Difficulty navigating stairs by the age if 18, and loss of ambulation at the age of 37 years. Neurological examination showed proximal symmetrical muscle weakness and wasting, along with calf muscle pseudohypertrophy.<ref>PMID:30345904</ref>
 
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== Function ==
 
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[https://www.uniprot.org/uniprot/PYRD1_HUMAN PYRD1_HUMAN] Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (PubMed:27745833). Required for normal sarcomere structure and muscle fiber integrity (By similarity).[UniProtKB:Q6PBT5]<ref>PMID:27745833</ref>
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Asanovic I]]
[[Category: Asanovic I]]

Current revision

Crystal Structure of human PYROXD1/FAD complex

PDB ID 6zk7

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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