7c02
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='7c02' size='340' side='right'caption='[[7c02]], [[Resolution|resolution]] 2.91Å' scene=''> | <StructureSection load='7c02' size='340' side='right'caption='[[7c02]], [[Resolution|resolution]] 2.91Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C02 FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c02 OCA], [https://pdbe.org/7c02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c02 RCSB], [https://www.ebi.ac.uk/pdbsum/7c02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c02 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c02 OCA], [https://pdbe.org/7c02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c02 RCSB], [https://www.ebi.ac.uk/pdbsum/7c02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c02 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/SPIKE_MERS1 SPIKE_MERS1] Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Interacts with host DPP4 to mediate virla entry.[HAMAP-Rule:MF_04099]<ref>PMID:23486063</ref> Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 24: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Middle East respiratory syndrome-related coronavirus]] | ||
[[Category: Dai L]] | [[Category: Dai L]] | ||
[[Category: Gao GF]] | [[Category: Gao GF]] | ||
[[Category: Qi J]] | [[Category: Qi J]] | ||
Current revision
Crystal structure of dimeric MERS-CoV receptor binding domain
| |||||||||||
Categories: Large Structures | Dai L | Gao GF | Qi J
