7cab

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Current revision (08:38, 17 October 2024) (edit) (undo)
 
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<StructureSection load='7cab' size='340' side='right'caption='[[7cab]], [[Resolution|resolution]] 3.52&Aring;' scene=''>
<StructureSection load='7cab' size='340' side='right'caption='[[7cab]], [[Resolution|resolution]] 3.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7cab]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CAB FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CAB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.52&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S, 2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2697049 2019-nCoV])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cab OCA], [https://pdbe.org/7cab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cab RCSB], [https://www.ebi.ac.uk/pdbsum/7cab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cab ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cab OCA], [https://pdbe.org/7cab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cab RCSB], [https://www.ebi.ac.uk/pdbsum/7cab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cab ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7cab" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7cab" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 2019-ncov]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cao, L]]
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[[Category: Cao L]]
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[[Category: Deng, Y]]
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[[Category: Deng Y]]
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[[Category: Qin, C]]
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[[Category: Qin C]]
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[[Category: Rao, Z]]
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[[Category: Rao Z]]
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[[Category: Sun, Y]]
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[[Category: Sun Y]]
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[[Category: Wang, N]]
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[[Category: Wang N]]
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[[Category: Wang, X]]
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[[Category: Wang X]]
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[[Category: Wang, Y]]
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[[Category: Wang Y]]
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[[Category: Xie, L]]
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[[Category: Xie L]]
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[[Category: Zhe, L]]
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[[Category: Zhe L]]
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[[Category: Sars-cov-2]]
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[[Category: Spike glycoprotein]]
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[[Category: Viral protein]]
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Current revision

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

PDB ID 7cab

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