7e7c
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e7c OCA], [https://pdbe.org/7e7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e7c RCSB], [https://www.ebi.ac.uk/pdbsum/7e7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e7c ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e7c OCA], [https://pdbe.org/7e7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e7c RCSB], [https://www.ebi.ac.uk/pdbsum/7e7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e7c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN] A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein. | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of ENL YEATS domain T1 mutant in complex with histone H3 acetylation at K27
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