7lga
From Proteopedia
(Difference between revisions)
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<StructureSection load='7lga' size='340' side='right'caption='[[7lga]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='7lga' size='340' side='right'caption='[[7lga]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LGA FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lga OCA], [https://pdbe.org/7lga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lga RCSB], [https://www.ebi.ac.uk/pdbsum/7lga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lga ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lga OCA], [https://pdbe.org/7lga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lga RCSB], [https://www.ebi.ac.uk/pdbsum/7lga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lga ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/PEG10_HUMAN PEG10_HUMAN]] Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis (PubMed:12810624). May also have a role in cell growth promotion and hepatoma formation (PubMed:12810624, PubMed:16423995). Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ACVRL1 (PubMed:15611116). When overexpressed, induces the formation of cellular extension, such as filipodia in association with ACVRL1 (PubMed:15611116). Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).[UniProtKB:Q7TN75]<ref>PMID:12810624</ref> <ref>PMID:15611116</ref> <ref>PMID:16423995</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ganser-Pornillos | + | [[Category: Ganser-Pornillos BK]] |
| - | [[Category: Pornillos | + | [[Category: Pornillos O]] |
| - | [[Category: Zurowska | + | [[Category: Zurowska K]] |
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Current revision
PEG10 CA-like C-terminal domain
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