7mil

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Current revision (08:59, 17 October 2024) (edit) (undo)
 
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<StructureSection load='7mil' size='340' side='right'caption='[[7mil]], [[Resolution|resolution]] 3.86&Aring;' scene=''>
<StructureSection load='7mil' size='340' side='right'caption='[[7mil]], [[Resolution|resolution]] 3.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7mil]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MIL FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MIL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.86&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Trpv3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mil OCA], [https://pdbe.org/7mil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mil RCSB], [https://www.ebi.ac.uk/pdbsum/7mil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mil ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mil OCA], [https://pdbe.org/7mil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mil RCSB], [https://www.ebi.ac.uk/pdbsum/7mil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mil ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[https://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7mil" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7mil" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Nadezhdin KD]]
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[[Category: Nadezhdin, K D]]
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[[Category: Neuberger A]]
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[[Category: Neuberger, A]]
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[[Category: Sobolevsky AI]]
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[[Category: Sobolevsky, A I]]
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[[Category: Membrane protein]]
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[[Category: Msp2n2]]
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[[Category: Sensitized state at 42 degrees celsius]]
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[[Category: Transient receptor potential v family member 3]]
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[[Category: Trp channel]]
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[[Category: Trpv3]]
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Current revision

Mouse TRPV3 in MSP2N2 nanodiscs, sensitized state at 42 degrees Celsius

PDB ID 7mil

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