7n8s
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n8s OCA], [https://pdbe.org/7n8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n8s RCSB], [https://www.ebi.ac.uk/pdbsum/7n8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n8s ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n8s OCA], [https://pdbe.org/7n8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n8s RCSB], [https://www.ebi.ac.uk/pdbsum/7n8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n8s ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/LORF2_HUMAN LORF2_HUMAN] Has a reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome.<ref>PMID:7516468</ref> <ref>PMID:8945517</ref> <ref>PMID:9140393</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
LINE-1 endonuclease domain complex with DNA
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