7p4t
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='7p4t' size='340' side='right'caption='[[7p4t]], [[Resolution|resolution]] 3.17Å' scene=''> | <StructureSection load='7p4t' size='340' side='right'caption='[[7p4t]], [[Resolution|resolution]] 3.17Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P4T FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.17Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.17Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p4t OCA], [https://pdbe.org/7p4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p4t RCSB], [https://www.ebi.ac.uk/pdbsum/7p4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p4t ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p4t OCA], [https://pdbe.org/7p4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p4t RCSB], [https://www.ebi.ac.uk/pdbsum/7p4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p4t ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/SAP_MOUSE SAP_MOUSE] Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.<ref>PMID:23690594</ref> Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.[UniProtKB:P07602] Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.[UniProtKB:P07602] Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).[UniProtKB:P07602] Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.[UniProtKB:P07602] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Mus musculus]] | ||
[[Category: Deane JE]] | [[Category: Deane JE]] | ||
[[Category: Shamin M]] | [[Category: Shamin M]] | ||
Current revision
Tetrameric structure of murine SapA
| |||||||||||
