7qox

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Current revision (09:07, 17 October 2024) (edit) (undo)
 
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qox OCA], [https://pdbe.org/7qox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qox RCSB], [https://www.ebi.ac.uk/pdbsum/7qox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qox ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qox OCA], [https://pdbe.org/7qox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qox RCSB], [https://www.ebi.ac.uk/pdbsum/7qox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qox ProSAT]</span></td></tr>
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== Disease ==
 
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[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[https://omim.org/entry/612423 612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
 
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== Function ==
 
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[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
 
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

Factor XI and Plasma Kallikrein apple domain structures reveals different kininogen bound complexes

PDB ID 7qox

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